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[This article belongs to Volume - 70, Issue - 9]
Published on : 2025-09-11 19:03:18
Article Code: AMJ-11-09-2025-12333
Title : Intravenous Lignocaine Infusion for the Management of Neuropathic Pruritus in a Patient with Neurofibromatosis
Author(s) : James Whitmore
Abstract :
Neurofibromatosis (NF) is an autosomal dominant neurocutaneous disorder. The itchiness suffered by
patients with NF is possibly caused by mast cells. However, transient receptor potential ankyrin 1 (TrpA1)
and transient receptor potential vanilloid 1 (TrpV1) have been recently discovered as mediators of
itchiness and pain in patients with NF. We reported a patient with NF, afflicted by neuropathic pain and
itch, despite despite receiving conservative treatment. Herein, we provided the patient lignocaine
infusion, which improved her pain and itch score by 50%. Additionally, her sleep quality, ability to perform
housework and engagement in leisure activities were improved. This case report highlights the therapeutic
value of lignocaine infusion when conservative treatment is ineffective for chronic neuropathic itch in
patients with neurofibromatosis through suppressing TrpA1 and TrpV1.