About the Article
Article Files
[This article belongs to Volume - 70, Issue - 9]
Published on : 2025-09-11 18:37:25
Article Code: AMJ-11-09-2025-12330
Title : Evaluating the Antibacterial Effectiveness of a Novel Intra-Canal Medicament Against Enterococcus faecalis Under Hyperthermic Conditions: An In Vitro Study
Author(s) : Muhammad M Mukaies, Aziz Abdullah, Asmahan Zinab
Abstract :
This study aims to compare the efficacy of three types of intracanal medicaments in eliminating
Enterococcus faecalis in cases of periapical abscess with systemic fever. The persistence of resistant
microorganisms, such as Enterococcus faecalis, contributes to the failure of endodontic treatment, a very
common problem in clinical practice. This study is particularly relevant under febrile conditions. The
research addresses the challenge of eradicating resistant bacterial strains that cause endodontic
infections, a significant factor in the failure of various intracanal medicaments. The study highlights the
importance of Hansedent Endomix, which was developed by Dr. Aziz Abdullah and patented under number
6075 on December 20, 2016. The study evaluates the antibacterial efficacy of Hansedent Endomix against
Enterococcus faecalis and compares it with Metronidazole and Ledermix in febrile conditions. The findings
revealed that Hansedent Endomix demonstrated significantly higher antibacterial activity, as indicated by
the inhibition zone diameter after 24 and 48 hours, in a sample of three plates against Enterococcus
faecalis. At a 5% significance level, Hansedent Endomix showed superior results compared to
Metronidazole and Ledermix under febrile conditions. This study provides valuable insights into the
superior efficacy of Hansedent Endomix and its potential application in resistant endodontic infections.