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[This article belongs to Volume - 70, Issue - 8]
Published on : 2025-08-11 20:32:22
Article Code: AMJ-11-08-2025-12326
Title : Study of laboratory parameters after hemodialysis for patients with chronic renal disease in Syrian patient
Author(s) : Seraj mresh, Suzanne Alshimali, Remal Abdulaziz Asaad
Abstract :
Background: Hemodialysis may elicit a series of changes in blood cells upon patients suffering from chronic kidney
disease(CKD).
Objective: The aim of this study was to evaluate the effects of hemodialysis on hematologic components and
coagulation systems in CKD patients.
Patients and Methods: A prospective study(Before&After) conducted in 70 patients with a diagnosis of CKD who
underwent hemodialysis. They were selected from department of Nephrology, Tishreen University Hospital in
Lattakia-Syria between June2021 and June2022. Venous blood samples were obtained from patients before initiating
hemodialysis and after session, in which laboratory parameters were compared between groups.
Results: Out of 70 patients, 42(60%) were males and 28(40%) were females, with median age of 52.76 ± 14.9 years.
The most frequent causes of CKD were hypertension (51.4%) and hyperglycemia (24.3%). As for the following
biological parameters, hemoglobin(Hb), red blood cell(RBC), prothrombin time(PT), activated partial thromboplastin
t
ime(aPTT), fibrinogen, Ca++, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), were increased
significantly post hemodialysis, while white blood count(WBC), neutrophil(Neut), platelets(PLT), mean platelet
volume (MPV), platelet distribution width (PDW), K+ showed an opposite pattern which were decreased significantly
after hemodialysis, p<0.05. After 72 hours from session, laboratory investigations were performed only in 21 patients
which showed that levels of RBC and Hb were decreased significantly compared with the baseline values(p<0.05).
Conclusion: Our study indicates that hemodialysis leads to significant changes in the levels of erythrocyte, platelets
parameters, coagulation profile, and inflammatory markers, in wwhich the monitoring of these parameters is
considered essential in management of CKD patients.